Computer Aided Design of Transformer Station Grounding System Using CDEGS Software

This paper presents a computer-aided design of a transformer station grounding system. Fault conditions in a transformer station can produce huge damage to transformer station equipment if the grounding system is not designed properly. A well designed grounding system is a very important part of the project for transformer station design as a whole. This paper analyses a procedure for transformer grounding system design and spatial distribution of touch and step voltage on the ground surface level, using the CDEGS (Current Distribution Electromagnetic Interference Grounding and Soil Structure Analysis) software. Spatial distribution is needed for checking and finding dangerous step and touch voltages above and around the transformer station. Apparent earth resistivity data is measured and analyzed using the RESAP module of the CDEGS software. Because of the very high current flow into the grounding system during a single line to ground fault or a three phase fault in the transformer station, very high and dangerous potentials can be induced on the metallic structures including the fence, which can cause dangerous situations for people and animals near the station and for the personnel inside the station. The PLOT module of CDEGS is used to view the results of the scalar potential, step and touch voltage on the surface. Graphic displays include equipotent contour lines and potential profiles (gradients) in 3D and 2D perspective and apparent soil resistivity (Wm) versus inter electrode spacing (m). The results of alternative grid designs may be displayed simultaneously for the purpose of comparison

Our first experience in laparoscopic colorectal operations

Purpose: It has been almost 23 years since the first laparoscopic-assisted right hemicolectomy was done when the surgeons in our institution started doing laparoscopic colorectal operations mainly for malignant diseases. The aim of this communication was to present the beginning of the laparoscopic colorectal operations in St. Naum University Clinic of Surgical Diseases in Skopje, Macedonia.Material and methods: Twenty patients with colorectal adenocarcinoma were laparoscopically operated during the period from December 2012 to June 2013. Eleven of them were men and the rest women at a mean age of 58 years. Eight of them were rectal cancers, 3 were cancers of the rectosigmoid and the rest 9 were sigmoid adenocarcinomas. The patients were operated with 4 ports (sigmoid cancer) and 5 ports (rectum). Medial-to-lateral approach was used in all the cases. Tumour location dictated whether high or low ligation of inferior mesenteric artery (IMA) was done. Double stapler technique was applied for distal resection and anastomosis creation.Results: Mean operating time was 315 min. There were no perioperative and early postoperative deaths. One patient was reoperated early at the same operating day for mesenteric venous bleeding. There was one case of anastomotic leakage and a laparotomy was done with temporary colostomy. One unit of blood was given to five patients due to perioperative bleeding. Mean length of hospital stay was six days. Per oral nutrition started at day 2. Mean bowel function returned after 3,5 days. There were two seromas of the minilaparotomy wounds and no cases of surgical site infection. Selected cases of sigmoid and rectal cancer were suitable for beginning of learning the laparoscopic colorectal resection technique. The long operating time was understandable due to the steep learning curve. Conclusion: Laparoscopic colorectal surgery is safe and oncologically routine surgical method. It is widely used for many benign colorectal diseases, too. Prolonged learning of this technique should not be discouraging

ANALYSING THE EFFECT OF DISCONTINUITY OF ELECTRICAL CONDUCTIVITY OF SOIL ON GROUND RESISTANCE

U članku je osim direktne primjene metode odslikavanja prikazana i primjena složenog odslikavanja, koje se javlja u slučajevima s dvije i više granica diskontinuiteta specifične električne vodljivosti. U radu je analiziran utjecaj zanemarenog odslikavanja pri određivanju otpora rasprostiranja uzemljivača, u slučaju kada se tlo modelira kao jednoslojno. Zatim je analizirana pogreška zbog modeliranja jednoslojnog tla koje se po svojoj naravi najtočnije opisuje kao dvoslojno. Prilikom modeliranja tla korištena je tehnika jednostavnog i složenog odslikavanja. Radi jednostavnosti izlaganja i usporedivosti modela za uzemljivač je odabran obični vodoravno ukopan cilindrični vodič. Dobiveni rezultati prikazani su analitički i grafički te objašnjeni.In addition to the direct application of the method of images the article also shows the application of complex images in the cases with two or more discontinuity boundaries of the specific electrical conductivity. The article analyzes the effect of neglected images in determining ground resistance, in a single-layer soil model, and goes on to analyse the error due to modelling single-layer soil which by its characteristics is most accurately described as double-layer. In modelling the soil the technique of simple and complex images was applied. To keep the presentation simple and make the models comparable, a normal horizontally inserted cylindrical conductor was taken as ground conductor. The results obtained are shown analytically and graphically and discussed

Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial

Background: chicken meat extract is a popular functional food in Asia. It is rich in the bioactive compounds carnosine and anserine, two histidine-containing dipeptides (HCD). Studies suggest that acute pre-exercise ingestion of chicken extracts has important applications towards exercise performance and fatigue control, but the evidence is equivocal. This study aimed to evaluate the ergogenic potential of the pre-exercise ingestion of a homemade chicken broth (CB) vs a placebo soup on a short-lasting, high-intensity cycling exercise. Methods: fourteen men participated in this double-blind, placebo-controlled, crossover intervention study. Subjects ingested either CB, thereby receiving 46.4 mg/kg body weight of HCD, or a placebo soup (similar in taste without HCD) 40 min before an 8 min cycling time trial (TT) was performed. Venous blood samples were collected at arrival (fasted), before exercise and at 5 min recovery. Plasma HCD were measured with UPLC-MS/MS and glutathione (in red blood cells) was measured through HPLC. Capillary blood samples were collected at different timepoints before and after exercise. Results: a significant improvement (p = 0.033; 5.2%) of the 8 min TT mean power was observed after CB supplementation compared to placebo. Post-exercise plasma carnosine (p <  0.05) and anserine (p <  0.001) was significantly increased after CB supplementation and not following placebo. No significant effect of CB supplementation was observed either on blood glutathione levels, nor on capillary blood analysis. Conclusions: oral CB supplementation improved the 8 min TT performance albeit it did not affect the acid-base balance or oxidative status parameters. Further research should unravel the potential role and mechanisms of HCD, present in CB, in this ergogenic approach

The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a twofold helical screw in the secondary plant cell wall of Arabidopsis thaliana.

The interaction between xylan and cellulose microfibrils is important for secondary cell wall properties in vascular plants; however, the molecular arrangement of xylan in the cell wall and the nature of the molecular bonding between the polysaccharides are unknown. In dicots, the xylan backbone of β-(1,4)-linked xylosyl residues is decorated by occasional glucuronic acid, and approximately one-half of the xylosyl residues are O-acetylated at C-2 or C-3. We recently proposed that the even, periodic spacing of GlcA residues in the major domain of dicot xylan might allow the xylan backbone to fold as a twofold helical screw to facilitate alignment along, and stable interaction with, cellulose fibrils; however, such an interaction might be adversely impacted by random acetylation of the xylan backbone. Here, we investigated the arrangement of acetyl residues in Arabidopsis xylan using mass spectrometry and NMR. Alternate xylosyl residues along the backbone are acetylated. Using molecular dynamics simulation, we found that a twofold helical screw conformation of xylan is stable in interactions with both hydrophilic and hydrophobic cellulose faces. Tight docking of xylan on the hydrophilic faces is feasible only for xylan decorated on alternate residues and folded as a twofold helical screw. The findings suggest an explanation for the importance of acetylation for xylan-cellulose interactions, and also have implications for our understanding of cell wall molecular architecture and properties, and biological degradation by pathogens and fungi. They will also impact strategies to improve lignocellulose processing for biorefining and bioenergy.The work conducted by TT and NN was supported by a grant from the BBSRC: BB/G016240/1 BBSRC Sustainable Energy Centre Cell Wall Sugars Programme (BSBEC) to PD and DNB. The work of PD was supported by the European Community’s Seventh Framework Programme SUNLIBB (FP7/2007-2013) under the grant agreement #251132. The NMR facility infrastructure was supported by the BBSRC and the Wellcome Trust. TCFG thanks CNPq (Brazil) for a graduate fellowship (grant # 140978/2009-7). MSS thanks CEPROBIO (grant # 490022/2009- 0) and FAPESP for funding (grant #2013/08293-7).This is the accepted version of the following article: "Busse-Wicher, M; Gomes, T.C.F; Tryfona, T; Nikolovski, N; Stott, K; Grantham, N.J; Bolam, D.N; Skaf, M.S; Dupree, P. (2014) "The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a two-fold helical screw in the secondary plant cell wall of Arabidopsis thaliana." The Plant Journal. Accepted article [electronic] 10.1111/tpj.12575", which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/tpj.12575/abstrac

Tissue Compatibility of Two Biodegradable Tubular Scaffolds Implanted Adjacent to Skin or Buccal Mucosa in Mice

Radiation therapy for cancer in the head and neck region leads to a marked loss of salivary gland parenchyma, resulting in a severe reduction of salivary secretions. Currently, there is no satisfactory treatment for these patients. To address this problem, we are using both tissue engineering and gene transfer principles to develop an orally implantable, artificial fluid-secreting device. In the present study, we examined the tissue compatibility of two biodegradable substrata potentially useful in fabricating such a device. We implanted in Balb/c mice tubular scaffolds of poly-L-lactic acid (PLLA), poly-glycolic acid coated with PLLA (PGA/PLLA), or nothing (sham-operated controls) either beneath the skin on the back, a site widely used in earlier toxicity and biocompatibility studies, or adjacent to the buccal mucosa, a site quite different functionally and immunologically. At 1, 3, 7, 14, and 28 days postimplantation, implant sites were examined histologically, and systemic responses were assessed by conventional clinical chemistry and hematology analyses. Inflammatory responses in the connective tissue were similar regardless of site or type of polymer implant used. However, inflammatory reactions were shorter and without epithelioid and giant cells in sham-operated controls. Also, biodegradation proceeded more slowly with the PLLA tubules than with the PGA/PLLA tubules. No significant changes in clinical chemistry and hematology were seen due to the implantation of tubular scaffolds. These results indicate that the tissue responses to PLLA and PGA/PLLA scaffolds are generally similar in areas subjacent to skin in the back and oral cavity. However, these studies also identified several potentially significant concerns that must be addressed prior to initiating any clinical applications of this device.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63126/1/107632702760240562.pd

Challenging assumptions of the enlargement literature : the impact of the EU on human and minority rights in Macedonia

This article argues that from the very start of the transition process in Macedonia, a fusion of concerns about security and democratisation locked local nationalist elites and international organisations intoa political dynamic that prioritised security over democratisation. This dynamic resulted in little progress in the implementation of human and minority rights until 2009, despite heavy EU involvement in Macedonia after the internal warfare of 2001. The effects of this informally institutionalised relationship have been overlooked by scholarship on EU enlargement towards Eastern Europe, which has made generalisations based on assumptions relevant to the democratisation of countries in Eastern Europe, but not the Western Balkans

A foundation for reliable spatial proteomics data analysis.

Quantitative mass-spectrometry-based spatial proteomics involves elaborate, expensive, and time-consuming experimental procedures, and considerable effort is invested in the generation of such data. Multiple research groups have described a variety of approaches for establishing high-quality proteome-wide datasets. However, data analysis is as critical as data production for reliable and insightful biological interpretation, and no consistent and robust solutions have been offered to the community so far. Here, we introduce the requirements for rigorous spatial proteomics data analysis, as well as the statistical machine learning methodologies needed to address them, including supervised and semi-supervised machine learning, clustering, and novelty detection. We present freely available software solutions that implement innovative state-of-the-art analysis pipelines and illustrate the use of these tools through several case studies involving multiple organisms, experimental designs, mass spectrometry platforms, and quantitation techniques. We also propose sound analysis strategies for identifying dynamic changes in subcellular localization by comparing and contrasting data describing different biological conditions. We conclude by discussing future needs and developments in spatial proteomics data analysis..G., C.M.M., and M.F. were supported by the European Union 7th Framework Program (PRIME-XS Project, Grant No. 262067). L.M.B. was supported by a BBSRC Tools and Resources Development Fund (Award No. BB/K00137X/1). T.B. was supported by the Proteomics French Infrastructure (ProFI, ANR-10-INBS-08). A.C. was supported by BBSRC Grant No. BB/D526088/1. A.J.G. was supported by BBSRC Grant No. BB/E024777/ and a generous gift from King Abdullah University for Science and Technology, Saudi Arabia. D.J.N.H. was supported by a BBSRC CASE studentship (BB/I016147/1)

Ergogenic effect of pre-exercise chicken broth ingestion on a high-intensity cycling time-trial

Background: chicken meat extract is a popular functional food in Asia. It is rich in the bioactive compounds carnosine and anserine, two histidine-containing dipeptides (HCD). Studies suggest that acute pre-exercise ingestion of chicken extracts has important applications towards exercise performance and fatigue control, but the evidence is equivocal. This study aimed to evaluate the ergogenic potential of the pre-exercise ingestion of a homemade chicken broth (CB) vs a placebo soup on a short-lasting, high-intensity cycling exercise. Methods: fourteen men participated in this double-blind, placebo-controlled, crossover intervention study. Subjects ingested either CB, thereby receiving 46.4 mg/kg body weight of HCD, or a placebo soup (similar in taste without HCD) 40 min before an 8 min cycling time trial (TT) was performed. Venous blood samples were collected at arrival (fasted), before exercise and at 5 min recovery. Plasma HCD were measured with UPLC-MS/MS and glutathione (in red blood cells) was measured through HPLC. Capillary blood samples were collected at different timepoints before and after exercise. Results: a significant improvement (p = 0.033; 5.2%) of the 8 min TT mean power was observed after CB supplementation compared to placebo. Post-exercise plasma carnosine (p < 0.05) and anserine (p < 0.001) was significantly increased after CB supplementation and not following placebo. No significant effect of CB supplementation was observed either on blood glutathione levels, nor on capillary blood analysis. Conclusions: oral CB supplementation improved the 8 min TT performance albeit it did not affect the acid-base balance or oxidative status parameters. Further research should unravel the potential role and mechanisms of HCD, present in CB, in this ergogenic approach